Endocrine Abstracts

Introduction: Every year 30 000 patients will suffer a traumatic brain injury (TBI) in The Netherlands. About two-thirds will develop post-TBI chronic fatigue (CF). Hormone deficiencies related to pituitary damage might contribute.Aim: To examine the clinical importance of hormonal and non-hormonal factors as issues contributing to chronic fatigue in post-TBI subjects.Patients and methods: The checklist individual strain (CIS), a w...

Introduction: Vitamin D deficiency is very common in Northern Europe. Recently, we developed an equation to calculate the vitamin D deficit, based on the serum 25-OH vitamin D3 (25OHD3) level and body weight: vitamin D deficit (IU)=40×(75−serum 25OHD3)×body weight. The calculated deficit gives the amount of cholecalciferol that is required to raise the serum 25OHD3 level to the target of 75 nmol/l.<p class="abstex...

Introduction: Severe vitamin D deficiency is very common in northern Europe. It is not limited to the elderly, but occurs in a large variety of subjects. Colecalciferol dosing guidelines for rapid correction of vitamin D deficiency are not available.Objective: To assess the optimal Colecalciferol dose regimen, based on body weight, for rapid correction of vitamin D deficiency, in a variety of subjects.Materials and methods: One hun...

Introduction: Hypogonadotropic hypogonadism is frequently observed in morbidly obese men, due to aromatase-dependent conversion of androgens to estrogens in adipocytes. The clinical impact of this sex hormone imbalance is not known.Aim: To evaluate the clinical effects of aromatase inhibition in obesity-related hypogonadotropic hypogonadism.Methods: Double-blind, placebo-controlled trial for 6 months in severely obese men (BMI &#62...